Isaac Knott (Nick Stahl) is a Public Radio reporter in New York City. When he was eight, his mother and father died in an automobile accident that left him in a wheelchair.

On air, Isaac recounts how he recently received an anonymous tip from someone identified only as "Ancient Chinese Girl." She tells him a perfectly able-bodied man walked into an emergency ward downtown, and attempted to bribe a doctor into amputating his leg.

As Isaac investigates the eerie tip, he encounters Fiona (Vera Farmiga) who, through her own quandary, leads Isaac to a netherworld of people afflicted with a perverse desire to be disabled. Like a contemporary noir detective film, "Quid Pro Quo" follows Issac as he embarks on a dream-like journey to pull back the layers of what makes people feel whole.